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Development

Pharmedartis chooses from a broad range of expression systems (bacteria, yeasts or mammalian cells) the suitable platform.

In particular, the CoMed™ vector system permits rapid and reliable simultaneously evaluation of the established yeast expression systems by featuring a variety of "universal" rDNA targeting sequences, selection markers and strong promoters.

Hansenula polymorpha, Pichia pastoris, Saccharomyces cerevisiae, Arxula sdeninivorans and Yarrowia lipotytica are subject to routine testing.

Employing the various methods and matrices for down-stream processing, e.g. AEX, CEX, IMAC, Protein A, Gel Filtration, we are able to purify the protein to the special needs of our customers.

An in-depth analysis of all process parameters leads to the definition of an optimal fermentation and purification process, which can be adequately controlled.