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Selected Publications

Amuel, C., Gellissen, G., Hollenberg, C.P., Suckow, M., 2000. Analysis of heat shock promoters in Hansenula polymorpha: the TPS1 promoter, a novel element for heterologous gene expression. Biotechnol. Bioprocess Eng. 5, 247-252.

Avgerinos, G.C., Turner, B.G., Gorelick, K.J., Papendieck, A., Weydemann, U., Gellissen, G., 2001. Production and preclinical analysis of H. polymorpha-derived PEG-hirudin. Sem. Thromb. Hemostas. 27, 357-371.

Barnes, C.S., Krafft, B., Frech, M., Hoffmann, U.R., Papendieck, A., Dahlems, U., Gellissen, G., Hoylarts, M.F., 2001. Production and characterization of saratin, an inhibitor of von Willebrand factor-dependent platelet adhesion to collagen. Semin. Thromb. Hemostas. 27, 337-347.

Bartelsen, O., Barnes, C.S., Gellissen, G., 2002. Production of anticoagulants in Hansenula polymorpha. In: Gellissen, G. (Ed.) Hansenula polymorpha – biology and applications. Wiley-VCH, Weinheim, pp. 211-228.

Böer, E., Gellissen, G., Kunze G., 2005. Arxula adeninivorans. In: Gellissen, G (Ed.) Production of recombinant proteins: Novel microbial and eukaryotic expression systems. Wiley VCH, Weinheim, pp. 89-110.

Böer, E., Steinborn, G., Kunze, G., Gellissen, G., 2007. Yeast expression platforms. Appl. Microbiol. Biotechnol. 77, 513-523.

Böer, E., Steinborn, G., Tag, K., Körner, M., Gellissen, G, Kunze, G., 2008. Arxula adeninivorans (Blastobotrys adeninivorans) – a dimorphic yeast of great biotechnological potential. In: Satyaranayana, T., Kunze, G. (Eds.) Yeast Biotechnology: Diversity and applications. Springer, Berlin (in press)

Böer, E., Steinborn, G., Gellissen, G., Kunze, G., 2007. Production of interleukin-6 in Arxula adeninivorans, Hansenula polymorpha and Saccharomyces cerevisiae by applying a wide-range yeast vector (CoMedTM) system to simultaneous comparative assessment. FEMS Yeast Res. 7, 1181-1187.

Brett, P.M., G. Melmer, M.M. Robertson, H.M.D. Gurling, 1993. A microsatellite polymorphism at the THRB locus. Hum Mol Genet 2, 1083

Curtis, D., G. Melmer, J. Brynjolfsson, D.S. Holmes, P. Brett, H. Petursson, L. Rifkin, P. Murphy, E., Sherrington, H.M.D Gurling, 1993. Genetic linkage analysis of manic depression in Iceland. J Roy Soc Med 86, 506-510

Curtis, D., J. Brynjolfsson, H. Petursson, D. Holmes, R. Sherrington, P. Brett, L. Rifkin, P. Murphy, E. Moloney, G. Melmer, H.M.D. Gurling, 1993. Segregation and linkage analysis in five manic depression pedigrees excludes the 5HT1a receptor gene (HTR1A). Ann Hum Genet 57, 27-39

Epplen, C., G.  Melmer, I.  Siedlaczck, F.-W. Schwaiger, W. Mäueler, J.T. Epplen, 1993. On the essence of "meaningless" simple repetitive DNA in eukaryote genomes. DNA Fingerprinting (Pena, S.D.J., Chakraborti, R., Epplen, J.T., Jeffreys, A.J. (eds.), Birkhäuser Verlag, Basel, pp. 29-45

Epplen, J.T., G. Melmer, P. Schmidt, J. Hundrieser, J. Buitkamp, 1992. On the potential of DNA fingerprinting for clinical,  forensic and evolutionary dynamic studies. Clin Invest 70, 1043-1051

Gellissen, G., 2000. Heterologous protein production in methylotrophic yeasts. Appl. Microbiol. Biotechnol. 54, 741-750.

Gellissen, G. (Ed.), 2002. Hansenula polymorpha – biology and applications. Wiley-VCH, Weinheim. ISBN 3-527-30341-3

Gellissen, G., Müller, F., Sieber, H., Tieke, A., Jenzelewski, V., Degelmann, A., Strasser, A.W.M., 2002. Production of cytokines in Hansenula polymorpha. In: Gellissen, G. (Ed.) Hansenula polymorpha – biology and applications. Wiley-VCH, Weinheim, pp. 229-254.

Gellissen, G. (Ed.), 2005. Production of recombinant proteins: novel microbial and eukaryotic expression systems. Wiley-VCH, Weinheim. ISBN 3-527-31036-3

Gellissen, G., Kunze, G., Gaillardin, C., Cregg, J.M., Berardi, E., Veenhuis, M., van der Klei, I., 2005. New yeast expression platforms based on methylotrophic Hansenula polymorpha and Pichia pastoris and dimorphic Arxula adeninivorans and Yarrowia lipolytica – a comparison. FEMS Yeast Res. 5, 1079-1096.

Gurling, H.M.D., P.F. Bolton, J. Vincent, G. Melmer, M. Rutter, 1997. Molecular and Cytogenetic Investigations of the Fragile X Region Including the Frax A and Trinucleotide Repeat Sequences in Families Multiplex for Autism and Related Phenotypes. Hum Heredity 47, 254-262

Hellwig, S., Stöckmann, C., Gellissen, G., Büchs, J., 2005. Comparative fermentation. In: Gellissen, G. (Ed.) Production of recombinant proteins: novel microbial and eukaryotic expression systems. Wiley-VCH, Weinheim, pp. 287-317.

Kalsi, G., B. Mankoo, D. Curtis, R. Sherrington, G. Melmer, J. Brynjolfsson, T. Sigmundsson, T. Read, P. Murphy, H. Petersson, H. Gurling, 1999. New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families. Ann Hum Genet 63, 235-247

Kang, H.A., Gellissen, G., 2004. Hansenula polymorpha. In: Gellissen, G (Ed.) Production of recombinant proteins: Novel microbial and eukaryotic expression systems. Wiley-VCH, Weinheim, pp. 111-142.

Kaur, P., Lingner, A., Singh, B., Böer,  E., Polajeva, J., Steinborn, G., Bode, R., Gellissen, G., Satyanarayana, T., Kunze, G., 2007. APHO1 from the yeast Arxula adeninivorans encodes an acid phosphatase of broad substrate specificity. A van Leeuwenhoek 91, 45-55.

Kunze, G., Kang, H.A., Gellissen, G., 2008. Hansenula polymorpha – biology and applications. In Satyaranayana, T., Kunze, G. (Eds.), Yeast Biotechnology: Diversity and applications. Springer, Berlin, pp. 45-62.

Mäueler, W., G. Frank, I. Siedlaczck, J.T. Epplen, G. Melmer, 1992. PCR amplification products are of limited use for the study of DNA-protein interaction. Electrophoresis 13, 641-643

Mankoo, B.S., R. Sherrington, G. Kalsi, G. Melmer, H.M.D. Gurling, 1992. Analysis of polymorphic microsatellite DNA sequences by PCR amplification: A method of genotyping deceased members of pedigrees in genetic linkage studies. Psychiatr Genet 2, 161-165

Melmer, G., M. Buchwald, 1992. Identification of genes using oligonucleotides corresponding to splice site consensus sequences. Hum Mol Gen 1, 433-438

Melmer G., 1992. Simple repeats are not found more abundant at G/C-rich regions. Electrophoresis 13, 639-640

Melmer, G., 1993. Molecular Genetics in Schizophrenia. Klin Lab 39, 627-636

Melmer, G., J.T. Epplen, 1993. Catching genes in the genomic desert in: A. Crambach, M.J. Dunn, B.J. Radola (Eds.) Advances in Electrophoresis Vol. 6, Verlag Chemie, Weinheim, pp. 180-265

Melmer, G., 1994. Zur Molekularbiologie der Fanconi Anämie. Klin Lab 40, 61-63

Melmer, G., 1994. Hybridization of the VNTR core oligonucleotide GNNGTGGG to 350 cosmids from chromosome 7. Electrophoresis 15, 175-176

Melmer, G., 1994. Zur Molekularbiologie des Morbus Huntington. Klin Lab 40, 64-66

Melmer, G., 1994. Die Totalsequenzierung des menschlichen Genoms und seine Auswirkungen für die klinische Diagnostik. Klin Lab 40, 459-463

Melmer, G., M. Buchwald, 1994. Screening cosmid libraries with oligonucleotides corresponding to splice site consensus sequences. Genet Anal Tech 11, 39-42

Melmer, G., 1995. Complete Sequencing of the Human Genome and the Consequences for Clinical Diagnostics. Klin Lab 40, 805-808

Melmer, G., 1995. Die Totalsequenzierung des menschlichen Genoms und seine Auswirkungen für die medizinische Diagnostik. Der Versuch einer Kosten-Nutzen-Analyse in einem neuen Markt für biotechnologische Produkte; Frankfurt am Main: Verlag Haag und Herchen

Melmer, G., T. Schwarz, 2001. Neue Kompatible Solute als allgemeines Schutzkonzept gegen Umweltstress? Kosmetische Medizin 1/2001, 20-23

Melmer, G., T. Schwarz, 2002. Ectoines: a new type of compatible Solutes with great commercial potential. UNESCO bibliography, EOLSS 6.73.4.4

Melmer, G., 2003. Capitalising on polymorphisms. World Pharmaceutical Frontiers, 85, 1

Melmer, G., 2003. Company Profile: GAG BioScience GmbH. Pharmacogenomics 4, 805-808

Melmer, G., 2004. High-throughput Single Nucleotide Polymorphism Screening in Human and Animal Health. Business Briefing: Future Drug Discovery, 1-3

Melmer, G., 2005. Biopharmaceuticals and the industrial environment. In: Gellissen, G. (Ed.), Production of recombinant proteins: novel microbial and eukaryotic expression systems. Wiley-VCH, Weinheim, pp. 361-383.

Melmer G, Kunze G, Gellissen G., 2008. Recombinant vaccine production in yeast. Biopharm. Intern. January suppl, 8-13.

Metzger, R., G. Melmer, S. Schondelmaier, B. Heckl-Östreicher, C. Nerl, J.T. Epplen, D. Kabelitz, 1993. Leukemic T cells from patients with chronic lymphocytic leukemia of T cell origin respond to Staphylococcus aureus enterotoxin superantigens. Scan J Immunol 37, 245-250

Mosner, J., G. Melmer, 2004. SNP-Analyseplattform. Transkript 10, 32

Müller, F. II, Tieke, A., Waschk, D., Mühle, C., Müller, F. I, Seigelchifer, M., Pesce, A., Jenzelewski, V., Gellissen, G., 2002. Production of IFNα-2a in Hansenula polymorpha. Proc. Biochem. 38, 15-25.

Oh, K.S., Kwon, O., Oh, Y.W., Sohn, M.J., Jung, S., Kim, Y.K., Kim, M.G., Rhee, S.K., Gellissen, G., Kang, H.A., 2004. Fabrication of a partial genome microarray of the methylotrophic yeast Hansenula polymorpha: Optimization and evaluation for transcript profiling. J. Microbiol. Biotechnol. 14, 1239-1248.

Papendieck, A., Dahlems, U., Gellissen, G., 2002. Technical enzyme production and whole-cell biocatalysis: application of Hansenula polymorpha. In: Gellissen, G. (Ed.) Hansenula polymorpha – biology and applications. Wiley-VCH, Weinheim, pp. 255-271.

Park, J.-N., Sohn, M.J., Oh, D.-B., Kwon, O., Rhee, S.K., Hur, C.-G., Lee, S.Y., Gellissen, G., Kang, H.A., 2007. Identification of the cadmium-inducible Hansenula polymorpha SEO1 gene promoter by transkriptome analysis and its application to whole-cell heavy-metal detection systems. Appl. Environm. Microbiol. 73, 5990-6000.

Riess, O., I. Siedlaczck, S. Kredtke, G. Melmer, J.T. Epplen, L.L. Deaven, 1993. Characterization of a human chromosome 4 flow sorted cosmid library. Cytogenet Cell Genet 65, 238-242

Sherrington,R., B.S. Mankoo, M. Dixon, D. Curtis, G. Kalsi, G. Melmer, H.M.D. Gurling, 1993. Microsatellite polymorphisms for chromosome 5 bands q11.2-q13.3. Hum Hered 43, 197-202

Steinborn, G., Böer, E., Scholz, A., Tag, K., Kunze, G., Gellissen, G., 2006. Application of a wide-range yeast vector (CoMedTM) system to recombinant protein production in dimorphic Arxula adeninivorans, methylotrophic Hansenula polymorpha and other yeasts. Microbial Cell Factories 5, 33.

Steinborn, G., Böer, E., Kunze, G., Gellissen, G., 2008. Application of the CoMedTM system. In: Satyaranayana T, Kunze G (Eds.) Yeast Biotechnology: Diversity and applications. Springer, Berlin (in press)

Stöckmann, C., Losen, M., Dahlems, U., Knocke, C., Gellissen, G., Büchs, J., 2003a. Effect of oxigen supply on passaging, stabilisation and screening of recombinant H. polymorpha production strains in test tubes cultures. FEMS Yeast Res. 4, 195-205.

Suckow, M., Gellissen, G., 2002. The expression platform based on Hansenula polymorpha RB11 - history, status and perspectives. In: Gellissen, G. (Ed.) Hansenula polymorpha – biology and applications. Wiley-VCH, Weinheim, pp.105-123.

Vincent, J., H.M.D. Gurling, G. Melmer, 1994. The use of short oligonucleotides in PCR for the amplification of rare restriction enzyme sites. DNA and Cell Biology 13, 75-82

Vincent, JB, G. Melmer, P. Bolton, S. Hodgkinson, D. Holmes, D. Curtis, H.M.D. Gurling, 2005. Genetic linkage analysis of the X chromosome in autism, with emphasis on the fragile fragile X region. Psychiatr Genet 15, 83 – 90. 

Wartmann, T., Stoltenburg, R., Böer, E., Sieber, H., Bartelsen, O., Gellissen, G., Kunze, G., 2003. The ALEU2 gene - a new component for an Arxula adeninivorans - based expression platform. FEMS Yeast Res. 3, 223-232.

Wartmann, T., Stephan, U.W., Bube, I., Böer, E., Melzer, M., Manteuffel, R., Stoltenburg, R., Guengerich, L., Gellissen, G., Kunze, G., 2002. Post-translational modifications of the AFET3 gene product – a component of the iron transport system in budding cells and mycelia of the yeast Arxula adeninivorans. Yeast 19, 849-862.

Weydemann, U., Keup, P., Piontek, M., Strasser, A.W.M., Schweden, J., Gellissen, G., 1995. High-level production of hirudin by Hansenula polymorpha – authentic processing of three different preprohirudins. Appl. Microbiol. Biotechnol. 44, 377-385.

Zurek, C., Kubis, E., Keup, P., Hörlein, D., Beunink, J., Thömmes, J., Kula, M.-R., Hollenberg, C.P., Gellissen, G., 1996. Production of two aprotinin variants in Hansenula polymorpha. Proc. Biochem. 31, 679-689.